Impact of immune checkpoint gene CD155 Ala67Thr and CD226 Gly307Ser polymorphisms on small cell lung cancer clinical outcome

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CD226 gene polymorphisms are associated with non-small-cell lung cancer in the Chinese Han population

BACKGROUND The immunoglobulin-like glycoprotein CD226 (DNAX accessory molecule-1) represents receptor-activating cytotoxic T lymphocyte and natural killer cells taking part in tumor surveillance, the pathogenesis of inflammation, and autoimmune disorders. The aim of the present study is to analyze the association between polymorphisms rs763361 and rs727088 in the CD226 gene and their impact on ...

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ژورنال

عنوان ژورنال: Scientific Reports

سال: 2021

ISSN: 2045-2322

DOI: 10.1038/s41598-021-81260-1